Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA017393-22
Application #
2086598
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1978-06-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Chung, Youn Jee; Kim, Hyun Jung; Park, Sang Ho et al. (2015) Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis. Int J Oncol 46:2039-46
Pépin, David; Sosulski, Amanda; Zhang, Lihua et al. (2015) AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A 112:E4418-27
Park, Joo Hyun; Tanaka, Yoshihiro; Arango, Nelson A et al. (2014) Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct regression. Dev Biol 386:227-36
Arango, Nelson Alexander; Li, Li; Dabir, Deepa et al. (2013) Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice. Biol Reprod 88:76
Pépin, D; Hoang, M; Nicolaou, F et al. (2013) An albumin leader sequence coupled with a cleavage site modification enhances the yield of recombinant C-terminal Mullerian Inhibiting Substance. Technology 1:63-71
Song, Jae Yen; Jo, Hyun Hee; Kim, Mee Ran et al. (2012) Expression of Müllerian inhibiting substance type II receptor and antiproliferative effects of MIS on human cervical cancer. Int J Oncol 40:2013-21
Namkung, Jeong; Song, Jae Yen; Jo, Hyun Hee et al. (2012) Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis. J Clin Endocrinol Metab 97:3224-30
Meirelles, Katia; Benedict, Leo Andrew; Dombkowski, David et al. (2012) Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance. Proc Natl Acad Sci U S A 109:2358-63
Hwang, Seong Jin; Suh, Min Jung; Yoon, Joo Hee et al. (2011) Identification of characteristic molecular signature of Müllerian inhibiting substance in human HPV-related cervical cancer cells. Int J Oncol 39:811-20
Clarkson, Andrew N; Talbot, Caroline L; Wang, Pei-Yu et al. (2011) Müllerian inhibiting substance is anterogradely transported and does not attenuate avulsion-induced death of hypoglossal motor neurons. Exp Neurol 231:304-8

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