Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA020424-13S1
Application #
3165291
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1984-12-01
Project End
1990-02-28
Budget Start
1988-12-01
Budget End
1990-02-28
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Roth, J; Goldstein, I J (1995) Subcellular distribution of terminal alpha-D- and beta-D-galactosyl residues in Ehrlich tumour cells studied by lectin-gold techniques. Glycoconj J 12:142-9
Song, Z; Varani, J; Goldstein, I J (1995) Expression and function of beta 1 integrins on adherent and nonadherent Ehrlich ascites tumor cells. Exp Cell Res 218:96-104
Roth, J; Li, W P; Knibbs, R N et al. (1994) Differential expression of cell surface sialoglycoconjugates on wild-type and cultured Ehrlich tumor cells as revealed by quantitative lectin-gold ultrastructural cytochemistry. Proc Natl Acad Sci U S A 91:11353-7
Chen, Y F; Boland, C R; Kraus, E R et al. (1994) The lectin Griffonia simplicifolia I-A4 (GS I-A4) specifically recognizes terminal alpha-linked N-acetylgalactosaminyl groups and is cytotoxic to the human colon cancer cell lines LS174t and SW1116. Int J Cancer 57:561-7
Knibbs, R N; MacCallum, D K; Lillie, J H et al. (1994) Wild-type and cultured Ehrlich ascites tumour cells differ in tumorigenicity, lectin binding patterns and binding to basement membranes. Glycobiology 4:419-28
Shigeta, S; Winter, H C; Goldstein, I J (1994) Alpha-(2-->3)- and alpha-(2-->6)-sialyltransferase activities present in three variants of Ehrlich tumor cells: identification of the products derived from N-acetyllactosamine and beta-D-Gal-(1-->3)-alpha-D-GalNAc-(1-->O)-Bn. Carbohydr Res 264:111-21
Knibbs, R N; Agrwal, N; Wang, J L et al. (1993) Carbohydrate-binding protein 35. II. Analysis of the interaction of the recombinant polypeptide with saccharides. J Biol Chem 268:14940-7
Song, Z; Varani, J; Goldstein, I J (1993) Differences in cell surface carbohydrates, and in laminin and fibronectin synthesis, between adherent and non-adherent Ehrlich ascites tumor cells. Int J Cancer 55:1029-35
Takagaki, M; Knibbs, R N; Roth, J et al. (1993) Monoclonal antibodies that recognize the trisaccharide epitope Gal alpha 1-3Gal beta 1-4GlcNAc present on Ehrlich tumor cell membrane glycoproteins. Histochemistry 100:139-47
Knibbs, R N; Osborne, S E; Glick, G D et al. (1993) Binding determinants of the sialic acid-specific lectin from the slug Limax flavus. J Biol Chem 268:18524-31

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