Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA021253-19
Application #
2086940
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1988-07-01
Project End
1998-06-30
Budget Start
1996-07-15
Budget End
1998-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Michigan State University
Department
Internal Medicine/Medicine
Type
Schools of Osteopathy
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824

  Publications

McCormick, J Justin; Maher, Veronica M (2011) Malignant transformation of human skin fibroblasts by two alternative pathways. Adv Exp Med Biol 720:191-207
Zhang, H; Marra, G; Jiricny, J et al. (2000) Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis 21:1639-46
Boley, S E; McManus, T P; Maher, V M et al. (2000) Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination. Cancer Res 60:4105-11
O'Reilly, S; Walicka, M; Kohler, S K et al. (1998) Dose-dependent transformation of cells of human fibroblast cell strain MSU-1.1 by cobalt-60 gamma radiation and characterization of the transformed cells. Radiat Res 150:577-84
McGregor, W G; Wei, D; Chen, R H et al. (1997) Relationship between adduct formation, rates of excision repair and the cytotoxic and mutagenic effects of structurally-related polycyclic aromatic carcinogens. Mutat Res 376:143-52
Wei, D; Maher, V M; McCormick, J J (1996) Site-specific excision repair of 1-nitrosopyrene-induced DNA adducts at the nucleotide level in the HPRT gene of human fibroblasts: effect of adduct conformation on the pattern of site-specific repair. Mol Cell Biol 16:3714-9
Reinhold, D S; Walicka, M; Elkassaby, M et al. (1996) Malignant transformation of human fibroblasts by ionizing radiation. Int J Radiat Biol 69:707-15
Wei, D; Maher, V M; McCormick, J J (1996) Effect of nuclear environment on the distribution of benzo[a]pyrene diol epoxide-induced adducts in the HPRT gene of human fibroblasts. Carcinogenesis 17:2695-701
McGregor, W G; Mah, M C; Chen, R W et al. (1995) Lack of correlation between degree of interference with transcription and rate of strand specific repair in the HPRT gene of diploid human fibroblasts. J Biol Chem 270:27222-7
Wei, D; Maher, V M; McCormick, J J (1995) Site-specific rates of excision repair of benzo[a]pyrene diol epoxide adducts in the hypoxanthine phosphoribosyltransferase gene of human fibroblasts: correlation with mutation spectra. Proc Natl Acad Sci U S A 92:2204-8

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