Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA023931-19
Application #
2087208
Study Section
Pathology B Study Section (PTHB)
Project Start
1978-09-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Starkey, Jason L; Chiari, Estelle F; Isom, Harriet C (2009) Hepatitis B virus (HBV)-specific short hairpin RNA is capable of reducing the formation of HBV covalently closed circular (CCC) DNA but has no effect on established CCC DNA in vitro. J Gen Virol 90:115-26
Heipertz Jr, Richard A; Starkey, Jason L; Miller, Thomas G et al. (2009) trans-Complementation of HBV rtM204I mutant replication by HBV wild-type polymerase. Virology 388:57-67
Shan, Weiwei; Palkar, Prajakta S; Murray, Iain A et al. (2008) Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci 105:418-28
Heipertz Jr, Richard A; Miller, Thomas G; Kelley, Colleen M et al. (2007) In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication. J Virol 81:3068-76
Bilello, John P; Cable, Edward E; Isom, Harriet C (2003) Expression of E-cadherin and other paracellular junction genes is decreased in iron-loaded hepatocytes. Am J Pathol 162:1323-38
Bilello, J P; Cable, E E; Myers, R L et al. (2003) Role of paracellular junction complexes in baculovirus-mediated gene transfer to nondividing rat hepatocytes. Gene Ther 10:733-49
Abdelhamed, Ayman M; Kelley, Colleen M; Miller, Thomas G et al. (2003) Comparison of anti-hepatitis B virus activities of lamivudine and clevudine by a quantitative assay. Antimicrob Agents Chemother 47:324-36
Iocca, Heather A; Isom, Harriet C (2003) Tumor necrosis factor-alpha acts as a complete mitogen for primary rat hepatocytes. Am J Pathol 163:465-76
Stoehr, Stephanie A; Isom, Harriet C (2003) Gap junction-mediated intercellular communication in a long-term primary mouse hepatocyte culture system. Hepatology 38:1125-35
Malecki, Elise A; Cable, Edward E; Isom, Harriet C et al. (2002) The lipophilic iron compound TMH-ferrocene [(3,5,5-trimethylhexanoyl)ferrocene] increases iron concentrations, neuronal L-ferritin, and heme oxygenase in brains of BALB/c mice. Biol Trace Elem Res 86:73-84

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