Research on the isolation and structure determination of several unknown, biologically active natural products is proposed. All of the structures would be unequivocally established by X-ray diffraction. Compounds from marine organisms, higher plants and microorganisms will be examined. Some specific targets are: 1. K112, K203 and K205, uncharacterized compounds with potential as chemotherapeutic agents in cancer treatment, 2. leucogenenol, a mammalian compound that stimulates wide spectrum myeloid differentiation from bone marrow precursors, and is capable of completing the peripheral T-cell differentiation cycles in the absence of the target thymus organ, 3. ciguatoxin, brevetoxin A and another, unnamed dinoflagellate toxin which appear to be highly unusual polyethers, 4. small antibiotic molecules from Tubastria spp., Uvaria spp. and Pseudopterogorgia bipinnata, 5. the bisintercalating antitumor antibiotic BBM-928A and its interactions with nucleic acids.
| Marks, Kevin M; Park, Eun Sun; Arefolov, Alexander et al. (2011) The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. J Nat Prod 74:567-73 |
| Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon et al. (2011) Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. PLoS One 6:e16763 |
| Seyedsayamdost, Mohammad R; Case, Rebecca J; Kolter, Roberto et al. (2011) The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem 3:331-5 |
| Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R et al. (2011) Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. Org Lett 13:752-5 |
| Dawlaty, Jessica; Zhang, Xiaorong; Fischbach, Michael A et al. (2010) Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases. J Nat Prod 73:441-6 |
| Cronan, John M; Lee, Angela; Liang, Jun et al. (2010) Chemical modification of the insecticidal briantheins X and Y. J Nat Prod 73:346-51 |
| Schloss, Patrick D; Allen, Heather K; Klimowicz, Amy K et al. (2010) Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin. DNA Cell Biol 29:533-41 |
| Crawford, Jason M; Kontnik, Renee; Clardy, Jon (2010) Regulating alternative lifestyles in entomopathogenic bacteria. Curr Biol 20:69-74 |
| Yamada, Koji; Hirotsu, Takaaki; Matsuki, Masahiro et al. (2010) Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science 329:1647-50 |
| D'Onofrio, Anthony; Crawford, Jason M; Stewart, Eric J et al. (2010) Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol 17:254-64 |
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