Research on the isolation and structure determination of biologically active natural products is proposed. The major emphasis will be on precisely defining the three-dimensional molecular structures of polyether macrolides, antitumor antibiotics, and heteropeptides by single crystal X-ray diffraction techniques. Specific projects described in the proposal include: 1. Compounds related to scytophycin such as tolytoxin, swinholide A, kabiramide, ulapualide, and halichondramide. 2. Antitumor antitiotics in the esperamicin and neocarzinostatin families. 3. Heteropeptides such as the theonellapeptolides, PD 124966, ulicyclamides, and didemnins. The molecular structure information obtained from this research will be of direct benefit to chemistry, biochemistry, and pharmacology. Several of the research targets could become useful drugs for the treatment of human diseases. The esperamicin antitumor antibiotics are especially promising as chemotherapeutic agents.
| Marks, Kevin M; Park, Eun Sun; Arefolov, Alexander et al. (2011) The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. J Nat Prod 74:567-73 |
| Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon et al. (2011) Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. PLoS One 6:e16763 |
| Seyedsayamdost, Mohammad R; Case, Rebecca J; Kolter, Roberto et al. (2011) The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem 3:331-5 |
| Oh, Dong-Chan; Poulsen, Michael; Currie, Cameron R et al. (2011) Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. Org Lett 13:752-5 |
| Dawlaty, Jessica; Zhang, Xiaorong; Fischbach, Michael A et al. (2010) Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases. J Nat Prod 73:441-6 |
| Cronan, John M; Lee, Angela; Liang, Jun et al. (2010) Chemical modification of the insecticidal briantheins X and Y. J Nat Prod 73:346-51 |
| Schloss, Patrick D; Allen, Heather K; Klimowicz, Amy K et al. (2010) Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin. DNA Cell Biol 29:533-41 |
| Crawford, Jason M; Kontnik, Renee; Clardy, Jon (2010) Regulating alternative lifestyles in entomopathogenic bacteria. Curr Biol 20:69-74 |
| Yamada, Koji; Hirotsu, Takaaki; Matsuki, Masahiro et al. (2010) Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science 329:1647-50 |
| D'Onofrio, Anthony; Crawford, Jason M; Stewart, Eric J et al. (2010) Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol 17:254-64 |
Showing the most recent 10 out of 108 publications
