Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025215-21
Application #
6375612
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Perry, Mary Ellen
Project Start
1979-05-01
Project End
2004-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
21
Fiscal Year
2001
Total Cost
$359,398
Indirect Cost
Name
Baylor College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Hollmann, C A; Kittrell, F S; Medina, D et al. (2001) Wnt-1 and int-2 mammary oncogene effects on the beta-catenin pathway in immortalized mouse mammary epithelial cells are not sufficient for tumorigenesis. Oncogene 20:7645-57
Kuperwasser, C; Hurlbut, G D; Kittrell, F S et al. (2000) Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. Am J Pathol 157:2151-9
Hollmann, C A; Medina, D; Butel, J S (2000) Transfection of mouse mammary epithelial cells. In Vitro Cell Dev Biol Anim 36:74-6
Jerry, D J; Kittrell, F S; Kuperwasser, C et al. (2000) A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene 19:1052-8
Bonnette, S G; Kittrell, F S; Stephens, L C et al. (1999) Interactions of apoptosis, proliferation and host age in the regression of the mouse mammary preneoplasia, TM3, carrying an unusual mutation in p53. Carcinogenesis 20:1715-20
Pinkas, J; Naber, S P; Butel, J S et al. (1999) Expression of MDM2 during mammary tumorigenesis. Int J Cancer 81:292-8
Medina, D; Stephens, L C; Bonilla, P J et al. (1998) Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: significance of p53 status and apoptosis. Mol Carcinog 22:199-207
Meyn, R E; Stephens, L C; Mason, K A et al. (1996) Radiation-induced apoptosis in normal and pre-neoplastic mammary glands in vivo: significance of gland differentiation and p53 status. Int J Cancer 65:466-72
Li, B; Kittrell, F S; Medina, D et al. (1995) Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein. Mol Carcinog 14:75-83
Donehower, L A; Godley, L A; Aldaz, C M et al. (1995) Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev 9:882-95

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