Our research covers six different areas related to the cellular evolution characteristic of primary melanomas and to the formal histogenetic precursors of malignant melanoma. These six areas of investigation are: (1) natural language access to the computerized database of all of the melanomas studied prospectively by the Pigmented Lesion Study Group of the University of Pennsylvania; (2) studies of dysplastic nevi, the important histogenetic precursors of melanoma, in familial and sporadic melanoma; (3) fine-structural studies of primary melanomas, dysplastic nevi, normal nevi, and Spitz tumors; (4) studies of the phenotypic characterizations of cells cultured from normal nevi, dysplastic nevi, and melanomas; (5) a variety of studies with antimelanoma monoclonal antibodies emphasizing their use with immunoperoxidase methods to detect melanoma-associated antigens in intact human tumors; and (6) studies of lymphocyte subsets in the host response to melanocytic neoplasms. (W)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025298-15
Application #
3166794
Study Section
Pathology B Study Section (PTHB)
Project Start
1978-08-01
Project End
1995-01-31
Budget Start
1993-02-01
Budget End
1994-01-31
Support Year
15
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Seykora, J; Elder, D (1996) Dysplastic nevi and other risk markers for melanoma. Semin Oncol 23:682-7
Elder, D E; Van Belle, P; Elenitsas, R et al. (1996) Neoplastic progression and prognosis in melanoma. Semin Cutan Med Surg 15:336-48
Elder, D E (1995) Skin cancer. Melanoma and other specific nonmelanoma skin cancers. Cancer 75:245-56
Clark Jr, W H (1995) The nature of cancer: morphogenesis and progressive (self)-disorganization in neoplastic development and progression. Acta Oncol 34:3-21
Clark, W H; Goldstein, A M; Tucker, M A (1995) Prospectives for cutaneous malignant melanoma. Considerations of the precursor state and heritability. Br Med Bull 51:717-46
Clark Jr, W H; Tucker, M A; Goldstein, A M (1995) Parenchymal-stromal interactions in neoplasia. Theoretical considerations and observations in melanocytic neoplasia. Acta Oncol 34:749-57
Carey Jr, W P; Thompson, C J; Synnestvedt, M et al. (1994) Dysplastic nevi as a melanoma risk factor in patients with familial melanoma. Cancer 74:3118-25
Isshiki, K; Seng, B A; Elder, D E et al. (1994) Chromosome 9 deletion in sporadic and familial melanomas in vivo. Oncogene 9:1649-53
Clark Jr, W H (1994) From the melanocyte to melanoma to tumor biology. Adv Cancer Res 65:113-40
Halpern, A C; Guerry 4th, D; Elder, D E et al. (1993) A cohort study of melanoma in patients with dysplastic nevi. J Invest Dermatol 100:346S-349S

Showing the most recent 10 out of 42 publications