Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA025933-16
Application #
2087429
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1979-07-01
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1996-12-31
Support Year
16
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wadsworth Center
Department
Type
DUNS #
110521739
City
Menands
State
NY
Country
United States
Zip Code
12204
Yin, Dezhong; Galivan, John; Ao, Wei et al. (2003) Characterization of the human gamma-glutamyl hydrolase promoter and its gene expression in human tissues and cancer cell lines. Gene 312:281-8
Chave, Karen J; Ryan, Thomas J; Chmura, Stacey E et al. (2003) Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene 319:167-75
Cole, P D; Kamen, B A; Gorlick, R et al. (2001) Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance. Cancer Res 61:4599-604
Sanchez-Alcazar, J A; Khodjakov, A; Schneider, E (2001) Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death. Cancer Res 61:1038-44
Sanchez-Alcazar, J A; Schneider, E; Martinez, M A et al. (2000) Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells. J Biol Chem 275:13353-61
Galivan, J; Ryan, T J; Chave, K et al. (2000) Glutamyl hydrolase. pharmacological role and enzymatic characterization. Pharmacol Ther 85:207-15
Chave, K J; Auger, I E; Galivan, J et al. (2000) Molecular modeling and site-directed mutagenesis define the catalytic motif in human gamma -glutamyl hydrolase. J Biol Chem 275:40365-70
Sanchez-Alcazar, J A; Ault, J G; Khodjakov, A et al. (2000) Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells. Cell Death Differ 7:1090-100
Volk, E L; Rohde, K; Rhee, M et al. (2000) Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux. Cancer Res 60:3514-21
Galivan, J; Ryan, T; Rhee, M et al. (1999) Glutamyl hydrolase: properties and pharmacologic impact. Semin Oncol 26:33-7

Showing the most recent 10 out of 61 publications