Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA027398-12S1
Application #
3167596
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1986-12-01
Project End
1991-11-30
Budget Start
1990-09-18
Budget End
1991-11-30
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost
Name
East Carolina University
Department
Type
Schools of Medicine
DUNS #
City
Greenville
State
NC
Country
United States
Zip Code
27858
Cory, J G; Cory, A H; Raber, N K et al. (1993) Structural aspects of N-hydroxy-N'-aminoguanidine derivatives as inhibitors of L1210 cell growth and ribonucleotide reductase activity. Adv Enzyme Regul 33:129-40
Cory, J G; Downes, D L; Ng, C Y et al. (1992) 5-hexyl-2'-deoxyuridine inhibition of nucleoside transport in L1210 cells. Oncol Res 4:175-9
Carter, G L; Cory, J G (1992) Factors affecting the mRNA levels for the non-heme iron and effector-binding subunits of ribonucleotide reductase. Adv Enzyme Regul 32:227-40
Cory, A H; Owen, T C; Barltrop, J A et al. (1991) Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun 3:207-12
Tihan, T; Elford, H L; Cory, J G (1991) Studies on the mechanisms of inhibition of L1210 cell growth by 3,4-dihydroxybenzohydroxamic acid and 3,4-dihydroxybenzamidoxime. Adv Enzyme Regul 31:71-83
Matsumoto, M; Tihan, T; Cory, J G (1990) Effect of ribonucleotide reductase inhibitors on the growth of human colon carcinoma HT-29 cells in culture. Cancer Chemother Pharmacol 26:323-9
Matsumoto, M; Weckbecker, G; Cory, J G (1990) Antineoplastic effect of the combination of 2,3-dihydro-1H-pyrazole[2,3a]imidazole plus deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine in mice with L1210 leukemia cells. Cancer Commun 2:1-6
Cory, J G; Halley, M C; Jeney, A et al. (1990) 5-Hexyl-2'-deoxyuridine blocks the cytotoxic effects of 5-fluorodeoxyuridine or deoxyadenosine in leukemia L1210 cells in culture. Cancer Res 50:4552-6
Weckbecker, G; Cory, J G (1989) Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2'-deoxyriboside to antitumor agents. Adv Enzyme Regul 28:125-44
Carter, G L; Cory, J G (1989) Selective resistance of L1210 cell lines to inhibitors directed at the subunits of ribonucleotide reductase. Adv Enzyme Regul 29:123-39

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