Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA027523-16
Application #
2087603
Study Section
Special Emphasis Panel (ZRG5-EI (03))
Project Start
1981-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Kremlev, S G; Chapoval, A I; Evans, R (1998) CSF-1 (M-CSF) enhances the inflammatory response of fibronectin-primed macrophages: pathways involved in activation of the cytokine network. Nat Immun 16:228-43
Chapoval, A I; Kamdar, S J; Kremlev, S G et al. (1998) CSF-1 (M-CSF) differentially sensitizes mononuclear phagocyte subpopulations to endotoxin in vivo: a potential pathway that regulates the severity of gram-negative infections. J Leukoc Biol 63:245-52
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Kamdar, S J; Fuller, J A; Evans, R (1997) CSF-1-induced and constitutive Il6 gene expression in mouse macrophages: evidence for PKC-dependent and -independent pathways. Exp Cell Res 232:439-42
Kamdar, S J; Fuller, J A; Nishikawa, S I et al. (1997) Priming of mouse macrophages with the macrophage colony-stimulating factor (CSF-1) induces a variety of pathways that regulate expression of the interleukin 6 (Il6) and granulocyte-macrophage colony-stimulating factor (Csfgm) genes. Exp Cell Res 235:108-16
Kamdar, S J; Chapoval, A I; Phelps, J et al. (1996) Differential sensitivity of mouse mononuclear phagocytes to CSF-1 and LPS: the potential in vivo relevance of enhanced IL-6 gene expression. Cell Immunol 174:165-72
Evans, R; Kamdar, S J; Fuller, J A et al. (1995) The potential role of the macrophage colony-stimulating factor, CSF-1, in inflammatory responses: characterization of macrophage cytokine gene expression. J Leukoc Biol 58:99-107
Evans, R; Kamdar, S J; Duffy, T M et al. (1995) The therapeutic efficacy of murine anti-tumor T cells: freshly isolated T cells are more therapeutic than T cells expanded in vitro. Anticancer Res 15:441-7
Krupke, D M; Fuller, J; Aslakson, C et al. (1994) Changes in tumor-associated NK 1.1+ large granular lymphocyte precursors after cyclophosphamide injection: in vitro characterization and potential therapeutic application. Nat Immun 13:246-57

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