Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA028379-16
Application #
2087724
Study Section
Virology Study Section (VR)
Project Start
1980-06-01
Project End
2000-12-31
Budget Start
1996-02-01
Budget End
1996-12-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Clippinger, Amy J; Maguire, Tobi G; Alwine, James C (2011) The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol 85:3930-9
Yu, Yongjun; Clippinger, Amy J; Pierciey Jr, Francis J et al. (2011) Viruses and metabolism: alterations of glucose and glutamine metabolism mediated by human cytomegalovirus. Adv Virus Res 80:49-67
Yu, Yongjun; Maguire, Tobi G; Alwine, James C (2011) Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection. J Virol 85:1573-80
Buchkovich, Nicholas J; Maguire, Tobi G; Alwine, James C (2010) Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection. J Virol 84:7005-17
Chambers, Jeremy W; Maguire, Tobi G; Alwine, James C (2010) Glutamine metabolism is essential for human cytomegalovirus infection. J Virol 84:1867-73
Buchkovich, Nicholas J; Yu, Yongjun; Pierciey Jr, Francis J et al. (2010) Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site. J Virol 84:11479-86
Buchkovich, Nicholas J; Maguire, Tobi G; Paton, Adrienne W et al. (2009) The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. J Virol 83:11421-8
Yu, Yongjun; Alwine, James C (2008) Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. J Virol 82:4521-6
Alwine, J C (2008) Modulation of host cell stress responses by human cytomegalovirus. Curr Top Microbiol Immunol 325:263-79
Buchkovich, Nicholas J; Yu, Yongjun; Zampieri, Carisa A et al. (2008) The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol 6:266-75

Showing the most recent 10 out of 45 publications