Abstract

Therapeutic failures in the treatment of human breast cancer are primarily the consequence of the dissemination of tumor cells prior to diagnosis. Immunotherapy, alone or in combination with other modalities, offers hope for the destruction of metastases. We have developed a rat mammary carcinoma system in which presurgical C. parvum destroys established metastases in lymph nodes and possibly lungs. This proposal will establish the importance of factors contributed by C. parvum, host immune responses and tumor cells in determining the outcome of treatment. This information will provide a rational basis for the design of treatments for residual metastases of human breast cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA029006-05
Application #
3168465
Study Section
Experimental Immunology Study Section (EI)
Project Start
1980-12-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Christensen, N D; Kreider, J W (1988) Helper and suppressor functions of panned populations of immune peritoneal T cells with reactivity to the rat mammary adenocarcinoma 13762A. Cell Immunol 112:200-13
Christensen, N D; Kreider, J W; Horetsky, R L (1988) Suppressor lymphokine produced by rat T-cells in response to syngeneic mammary adenocarcinoma 13762A. Cancer Res 48:943-9
Osbakken, M D; Kreider, J W; Taczanowsky, P (1986) Nuclear magnetic resonance imaging characterization of a rat mammary tumor. Magn Reson Med 3:1-9
Kreider, J W; Bartlett, G L (1986) Is there a host response to metastasis? Prog Clin Biol Res 212:61-76
Howell, L E; Kreider, J W; Bartlett, G L (1986) Role of T-cell subsets in the destruction of established metastases of 13762A rat mammary adenocarcinoma. J Natl Cancer Inst 77:187-93
Christensen, N D; Kreider, J W; Bartlett, G L et al. (1986) Distinct T-cell proliferative responses to 13762A rat mammary adenocarcinoma and derived clones. Cell Immunol 97:433-45
Kreider, J W; Howell, L E; Bartlett, G L (1985) Characteristics of T cells involved in the expression of delayed hypersensitivity and tumor rejection immunity to 13762A rat mammary adenocarcinoma. Cell Immunol 93:26-37
Kreider, J W; Bartlett, G L; Christensen, N D et al. (1985) Systemic adoptive transfer of immunity and low-dose irradiation eradicate metastases of 13762A rat mammary adenocarcinoma. Int J Cancer 36:217-24
Kreider, J W; Bartlett, G L (1985) Increased immunogenicity of a spontaneous variant clone of the 13762A rat mammary adenocarcinoma. J Natl Cancer Inst 75:141-9
Kreider, J W; Bartlett, G L (1985) Shope rabbit papilloma--carcinoma complex. A model system of HPV infections. Clin Dermatol 3:20-6