Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA032250-04
Application #
3170233
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1982-07-01
Project End
1985-12-31
Budget Start
1985-07-01
Budget End
1985-12-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Sri International
Department
Type
DUNS #
City
Menlo Park
State
CA
Country
United States
Zip Code
94025
Acton, E M; Tong, G L; Taylor, D L et al. (1986) N-(cyanomethyl)- and N-(2-methoxy-1-cyanoethyl)anthracyclines and related carboxyl derivatives. J Med Chem 29:2074-9
Acton, E M; Tong, G L; Smith, T H et al. (1986) N-(2-hydroxyethyl)doxorubicin from hydrolysis of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin. J Med Chem 29:2120-2
Acton, E M; Tong, G L; Taylor, D L et al. (1986) New cyanomorpholinyl byproduct of doxorubicin reductive alkylation. J Med Chem 29:1225-30
Sikic, B I; Ehsan, M N; Harker, W G et al. (1985) Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog. Science 228:1544-6
Acton, E M (1985) Anthracycline mechanisms in analogue selection. Drugs Exp Clin Res 11:1-8