Abstract

The goal of this research is to establish cultures of human medullary carcinoma and study the molecular forms of calcitonin produced and the regulation of this process. Since this research has been active for only 2 months, the progress has been limited. Several different calcitonin-producing cultures derived from human medullary carcinoma of the thyroid (MCT) have been carried for 6 months. The appearance of the cells and the relatively high calcitonin concentrations in the medium strongly indicate that one or more continuous tumor cell lines from MCT will be available for experiments in the very near future. (1)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA033207-03
Application #
3171150
Study Section
Pathology B Study Section (PTHB)
Project Start
1983-03-01
Project End
1986-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Dartmouth College
Department
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code

  Publications

Gosselin, E J; Cate, C C; Pettengill, O S et al. (1986) Immunocytochemistry: its evolution and criteria for its application in the study of epon-embedded cells and tissue. Am J Anat 175:135-60
Cate, C C; Pettengill, O S; Sorenson, G D (1986) Biosynthesis of procalcitonin in small cell carcinoma of the lung. Cancer Res 46:812-8
Wurster-Hill, D H; Noll, W W; Bircher, L Y et al. (1986) Cytogenetics of medullary carcinoma of the thyroid. Cancer Genet Cytogenet 20:247-53
Gosselin, E J; Dennett, J C; Sorenson, G D et al. (1985) Immunocytochemical staining of cytocentrifuge prepared cultured cells: nonspecific staining and its elimination. Histochem J 17:847-58