Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA033497-09S1
Application #
3171338
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1982-09-01
Project End
1993-07-31
Budget Start
1992-09-30
Budget End
1993-07-31
Support Year
9
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Type
Schools of Pharmacy
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Ramasamy, Kumaraguruparan; Dwyer-Nield, Lori D; Serkova, Natalie J et al. (2011) Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies. Clin Cancer Res 17:753-61
Fritz, Jason M; Dwyer-Nield, Lori D; Malkinson, Alvin M (2011) Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation. Mol Cancer 10:76
Reynolds, Susan D; Malkinson, Alvin M (2010) Clara cell: progenitor for the bronchiolar epithelium. Int J Biochem Cell Biol 42:1-4
Rice, Pamela L; Barrett, Bradley S; Fritz, Jason M et al. (2010) Regulation of cytokine-induced prostanoid and nitric oxide synthesis by extracellular signal–regulated kinase 1/2 in lung epithelial cells. Exp Lung Res 36:558-71
Dwyer-Nield, Lori D; McQuillan, Jay; Hill-Baskin, Annie et al. (2010) Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains. Int J Cancer 126:125-32
Redente, Elizabeth F; Higgins, David M; Dwyer-Nield, Lori D et al. (2010) Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation. J Leukoc Biol 88:159-68
Fritz, Jason M; Dwyer-Nield, Lori D; Russell, Bridgette M et al. (2010) The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers. J Thorac Oncol 5:254-7
Redente, Elizabeth F; Dwyer-Nield, Lori D; Barrett, Bradley S et al. (2009) Lung tumor growth is stimulated in IFN-gamma-/- mice and inhibited in IL-4Ralpha-/- mice. Anticancer Res 29:5095-101
Tyagi, Alpna; Singh, Rana P; Ramasamy, Kumaraguruparan et al. (2009) Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila) 2:74-83
Lin, Sui; Ikegami, Machiko; Xu, Yan et al. (2008) Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol 316:441-55

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