This is an epidemiologic prospective study to identify biochemical, dietary and other factors related to cancer occurring among American Japanese men living in Hawaii. The proposal is focused on two specific cancer sites: the prostate and colon.
Five specific aims will be addressed: l) to determine if dietary fat or vitamin A intake increases prostate cancer risk; 2) to study the association of serum levels of vitamin A and carotenoids with prostate cancer risk, using pre-diagnostic serum; 3) to see if elevated serum levels of adrenal androgens and other androgens (androsterone glucuronide and 5-alpha-androstane-3-alpha, 17- beta-diol glucuronide) increase prostate cancer risk; 4) to see if a high intake of dietary fat increases colon cancer risk; 5) to determine if high serum levels of vitamin D protect against colon cancer.
| Stemmermann, G N; Nomura, A M Y (2006) The relation of pepsinogen group II (PGII) expression to intestinal metaplasia and gastric cancer. Histopathology 49:45-51 |
| Tsushima, Matthew; Nomura, Abraham M Y; Lee, James et al. (2005) Prospective study of the association of serum triglyceride and glucose with colorectal cancer. Dig Dis Sci 50:499-505 |
| Nomura, Abraham M Y; Hankin, Jean H; Lee, James et al. (2004) Cohort study of tofu intake and prostate cancer: no apparent association. Cancer Epidemiol Biomarkers Prev 13:2277-9 |
| Nomura, Abraham M Y; Lee, James; Stemmermann, Grant N et al. (2003) Serum vitamins and the subsequent risk of bladder cancer. J Urol 170:1146-50 |
| Nomura, Abraham M Y; Stemmermann, Grant N; Lee, James et al. (2003) Serum insulin-like growth factor I and subsequent risk of colorectal cancer among Japanese-American men. Am J Epidemiol 158:424-31 |
| Nomura, Abraham M Y; Lee, James; Stemmermann, Grant N et al. (2002) Helicobacter pylori CagA seropositivity and gastric carcinoma risk in a Japanese American population. J Infect Dis 186:1138-44 |
| Nomura, Abraham M Y; Perez-Perez, Guillermo I; Lee, James et al. (2002) Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am J Epidemiol 155:1054-9 |
| Nomura, A M (2001) Body size and prostate cancer. Epidemiol Rev 23:126-31 |
| Masaki, K H; Losonczy, K G; Izmirlian, G et al. (2000) Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 54:1265-72 |
| Nomura, A M; Lee, J; Stemmermann, G N et al. (2000) Serum selenium and subsequent risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 9:883-7 |
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