Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA034627-19S1
Application #
6778648
Study Section
Cancer Etiology Study Section (CE)
Program Officer
Rosenfeld, Bobby
Project Start
1989-09-01
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
19
Fiscal Year
2004
Total Cost
$114,538
Indirect Cost

  Institution

Name
University of Louisville
Department
Pharmacology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Hein, David W; Zhang, Xiaoyan; Doll, Mark A (2018) Role of N-acetyltransferase 2 acetylation polymorphism in 4, 4'-methylene bis (2-chloroaniline) biotransformation. Toxicol Lett 283:100-105
Zhang, Xiaoyan; Carlisle, Samantha M; Doll, Mark A et al. (2018) High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5?-androstane-3?,17?-Diol, or Dihydrotestosterone in Breast Cancer Cells. J Pharmacol Exp Ther 365:84-93
Hein, David W; Doll, Mark A (2017) Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype. Arch Toxicol 91:2827-2835
Hein, David W; Doll, Mark A (2017) Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens. Arch Toxicol 91:3185-3188
Stepp, Marcus W; Doll, Mark A; Samuelson, David J et al. (2017) Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism. BMC Cancer 17:233
Middlebrooks, Candace D; Banday, A Rouf; Matsuda, Konichi et al. (2016) Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors. Nat Genet 48:1330-1338
Carlisle, Samantha M; Trainor, Patrick J; Yin, Xinmin et al. (2016) Untargeted polar metabolomics of transformed MDA-MB-231 breast cancer cells expressing varying levels of human arylamine N-acetyltransferase 1. Metabolomics 12:
Lavender, Nicole; Hein, David W; Brock, Guy et al. (2015) Evaluation of Oxidative Stress Response Related Genetic Variants, Pro-oxidants, Antioxidants and Prostate Cancer. AIMS Med Sci 2:271-294
Figueroa, Jonine D; Ye, Yuanqing; Siddiq, Afshan et al. (2014) Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet 23:1387-98
Figueroa, Jonine D; Han, Summer S; Garcia-Closas, Montserrat et al. (2014) Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis 35:1737-44

Showing the most recent 10 out of 174 publications