Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA035519-12A2
Application #
2088986
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1983-07-01
Project End
2001-02-28
Budget Start
1996-05-01
Budget End
1997-02-28
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Sun, Yuan-Wan; Guttenplan, Joseph B; Cooper, Timothy et al. (2013) Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat. Chem Res Toxicol 26:547-54
Krzeminski, Jacek; Kropachev, Konstantin; Reeves, Dara et al. (2013) Adenine-DNA adduct derived from the nitroreduction of 6-nitrochrysene is more resistant to nucleotide excision repair than guanine-DNA adducts. Chem Res Toxicol 26:1746-54
Krzeminski, Jacek; Kropachev, Konstantin; Kolbanovskiy, Marina et al. (2011) Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene. Chem Res Toxicol 24:65-72
Sun, Yuan-Wan; Guttenplan, Joseph B; Khmelnitsky, Michael et al. (2009) Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell li Chem Res Toxicol 22:1992-7
Sun, Yuan-Wan; Herzog, Christopher R; Krzeminski, Jacek et al. (2007) Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells. Chem Biol Interact 170:31-9
Guttenplan, Joseph B; Zhao, Zhong-lin; Kosinska, Wieslawa et al. (2007) Comparative mutational profiles of the environmental mammary carcinogen, 6-nitrochrysene and its metabolites in a lacI mammary epithelial cell line. Carcinogenesis 28:2391-7
Boyiri, Telih; Guttenplan, Joseph; Khmelnitsky, Michael et al. (2004) Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene. Carcinogenesis 25:637-43
Sun, Yuan-Wan; Guengerich, F Peter; Sharma, Arun K et al. (2004) Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. Chem Res Toxicol 17:1077-85
El-Bayoumy, Karam; Sharma, Arun K; Lin, Jyh-Ming et al. (2004) Identification of 5-(deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the major DNA lesion in the mammary gland of rats treated with the environmental pollutant 6-nitrochrysene. Chem Res Toxicol 17:1591-9
Amin, Shantu; Lin, Jyh-Ming; Krzeminski, Jacek et al. (2003) Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats. Chem Res Toxicol 16:227-31

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