Abstract

The activation of CD4 T cells can lead to the generation of antigen experienced cells some of which are effector cells important in the immediate clearance of pathogens and some of which are memory cells important in the rapid elicitation of a response to pathogens encountered previously. The main goal of this proposal is to study the events leading to the generation of antigen experienced CD4 T. Once generated naive and antigen experienced cells will be analyzed for differences in their activation requirements and in the nature of the response elicited. The project will consist of 2 parts: 1) the characterization of phenotypic, functional and biochemical differences between naive, memory and effector CD4 T cells, and 2) the examination of the role of antigen presenting cell types and cytokine expression in the development of effector and memory cells from naive CD4 T cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA038350-14
Application #
2089544
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1984-03-01
Project End
1999-01-31
Budget Start
1994-04-01
Budget End
1995-01-31
Support Year
14
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Chen, Jonathan H; Perry, Curtis J; Tsui, Yao-Chen et al. (2015) Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Nat Med 21:327-34
Whitmire, Jason K; Asano, Mary S; Kaech, Susan M et al. (2009) Requirement of B cells for generating CD4+ T cell memory. J Immunol 182:1868-76
Jackman, Rachael P; Balamuth, Fran; Bottomly, Kim (2007) CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets. J Immunol 178:5543-51
Meyer zum Bueschenfelde, Christian O; Unternaehrer, Julia; Mellman, Ira et al. (2004) Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. J Immunol 173:6119-24
Czyzyk, Jan; Brogdon, Jennifer L; Badou, Abdallah et al. (2003) Activation of CD4 T cells by Raf-independent effectors of Ras. Proc Natl Acad Sci U S A 100:6003-8
Boursalian, T E; Bottomly, K (1999) Stability of naive and memory phenotypes on resting CD4 T cells in vivo. J Immunol 162:9-16
Boursalian, T E; Bottomly, K (1999) Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu. J Immunol 162:3795-801
Metz, D P; Farber, D L; Taylor, T et al. (1998) Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J Immunol 161:5855-61
Farber, D L; Acuto, O; Bottomly, K (1997) Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. Eur J Immunol 27:2094-101
Metz, D P; Farber, D L; Konig, R et al. (1997) Regulation of memory CD4 T cell adhesion by CD4-MHC class II interaction. J Immunol 159:2567-73

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