Abstract

The long term objective of this continuing research is to achieve accurate tumor dosimetry from external imaging. A focus is to establish a strong relationship between res- ponse and dosimetric variables. The investigators seek to establish cost effective treatment of patients with non-Hodgkin s lymphoma by administration of a combination regimen of non-radioactive plus I-131 labelled anti-B1 monoclonal antibody. A primary goal is to be able to select patients appropriately for this non- marrow-ablative therapy. The three specific aims are: (1) to analyze and refine the existing protocol for measuring tumor dosimetry, (2) to apply the protocol to non-Hodgkin s lymphoma patients who are being treated with the combined anti-B1 therapy for determination of the relationships between dosimetric variables and response of both the patient as a whole and of individual tumors, and (3) to establish a method to predict outcome of therapy from tracer studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA038790-14
Application #
2882325
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Stone, Helen B
Project Start
1985-09-01
Project End
2000-09-21
Budget Start
1999-03-01
Budget End
2000-09-21
Support Year
14
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Koral, Kenneth F; Dewaraja, Yuni; Li, Jia et al. (2003) Update on hybrid conjugate-view SPECT tumor dosimetry and response in 131I-tositumomab therapy of previously untreated lymphoma patients. J Nucl Med 44:457-64
Koral, Kenneth F; Francis, Isaac R; Kroll, Stewart et al. (2002) Volume reduction versus radiation dose for tumors in previously untreated lymphoma patients who received iodine-131 tositumomab therapy. Conjugate views compared with a hybrid method. Cancer 94:1258-63
Koral, K F; Dewaraja, Y; Clarke, L A et al. (2000) Tumor-absorbed-dose estimates versus response in tositumomab therapy of previously untreated patients with follicular non-Hodgkin's lymphoma: preliminary report. Cancer Biother Radiopharm 15:347-55
Dewaraja, Y K; Ljungberg, M; Koral, K F (2000) Characterization of scatter and penetration using Monte Carlo simulation in 131I imaging. J Nucl Med 41:123-30
Dewaraja, Y K; Ljungberg, M; Koral, K F (2000) Accuracy of 131I tumor quantification in radioimmunotherapy using SPECT imaging with an ultra-high-energy collimator: Monte Carlo study. J Nucl Med 41:1760-7
Koral, K F; Dewaraja, Y; Li, J et al. (2000) Initial results for Hybrid SPECT--conjugate-view tumor dosimetry in 131I-anti-B1 antibody therapy of previously untreated patients with lymphoma. J Nucl Med 41:1579-86
Koral, K F; Li, J; Dewaraja, Y et al. (1999) I-131 anti-B1 therapy/tracer uptake ratio using a new procedure for fusion of tracer images to computed tomography images. Clin Cancer Res 5:3004s-3009s
Koral, K F; Lin, S; Fessler, J A et al. (1997) Preliminary results from intensity-based CT-SPECT fusion in I-131 anti-B1 monoclonal-antibody therapy of lymphoma. Cancer 80:2538-44
Luo, J Q; Koral, K F; Ljungberg, M et al. (1995) A Monte Carlo investigation of dual-energy-window scatter correction for volume-of-interest quantification in 99Tcm SPECT. Phys Med Biol 40:181-99
Koral, K F; Zasadny, K R; Kessler, M L et al. (1994) CT-SPECT fusion plus conjugate views for determining dosimetry in iodine-131-monoclonal antibody therapy of lymphoma patients. J Nucl Med 35:1714-20

Showing the most recent 10 out of 21 publications