Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA039225-12
Application #
2089765
Study Section
Special Emphasis Panel (ZRG3-PTHB (01))
Project Start
1996-02-16
Project End
2000-12-31
Budget Start
1996-02-16
Budget End
1996-12-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Sirica, Alphonse E; Gores, Gregory J (2014) Desmoplastic stroma and cholangiocarcinoma: clinical implications and therapeutic targeting. Hepatology 59:2397-402
Liu, Runping; Zhao, Renping; Zhou, Xiqiao et al. (2014) Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. Hepatology 60:908-18
Fingas, Christian D; Mertens, Joachim C; Razumilava, Nataliya et al. (2013) Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma. Hepatology 58:1362-74
Mertens, Joachim C; Fingas, Christian D; Christensen, John D et al. (2013) Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma. Cancer Res 73:897-907
Campbell, Deanna J W; Dumur, Catherine I; Lamour, Nadia F et al. (2012) Novel organotypic culture model of cholangiocarcinoma progression. Hepatol Res 42:1119-30
Fingas, Christian D; Mertens, Joachim C; Razumilava, Nataliya et al. (2012) Targeting PDGFR-? in Cholangiocarcinoma. Liver Int 32:400-9
Sirica, Alphonse E (2012) The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma. Nat Rev Gastroenterol Hepatol 9:44-54
Sirica, Alphonse E; Campbell, Deanna J; Dumur, Catherine I (2011) Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma. Curr Opin Gastroenterol 27:276-84
Fingas, Christian D; Bronk, Steven F; Werneburg, Nathan W et al. (2011) Myofibroblast-derived PDGF-BB promotes Hedgehog survival signaling in cholangiocarcinoma cells. Hepatology 54:2076-88
Fingas, Christian D; Blechacz, Boris R A; Smoot, Rory L et al. (2010) A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells. Hepatology 52:550-61

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