Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA039259-12
Application #
2089799
Study Section
Virology Study Section (VR)
Project Start
1985-04-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1998-01-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Conzen, S D; Snay, C A; Cole, C N (1997) Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen. J Virol 71:4536-43
Anderson, M M; Chen, J; Cole, C N et al. (1996) Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites. J Virol 70:6304-13
Conzen, S D; Cole, C N (1995) The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts. Oncogene 11:2295-302
Rajan, P; Swaminathan, S; Zhu, J et al. (1995) A novel translational regulation function for the simian virus 40 large-T antigen gene. J Virol 69:785-95
Del Sal, G; Ruaro, E M; Utrera, R et al. (1995) Gas1-induced growth suppression requires a transactivation-independent p53 function. Mol Cell Biol 15:7152-60
Feldherr, C; Cole, C; Lanford, R E et al. (1994) The effects of SV40 large T antigen and p53 on nuclear transport capacity in BALB/c 3T3 cells. Exp Cell Res 213:164-71
Rice, P W; Cole, C N (1993) Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen. J Virol 67:6689-97
Zhu, J; Rice, P W; Gorsch, L et al. (1992) Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen. J Virol 66:2780-91
Heath, C V; Fanning, E; Cole, C N (1992) Adenovirus helper function activity of simian virus 40 T antigen mutants. Virology 189:762-5
Zhu, J Y; Abate, M; Rice, P W et al. (1991) The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J Virol 65:6872-80

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