Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA041843-08
Application #
2090527
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1986-09-30
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Branda, Richard F; Chen, Zhuan; Brooks, Elice M et al. (2002) Diet modulates the toxicity of cancer chemotherapy in rats. J Lab Clin Med 140:358-68
Branda, Richard F; Brooks, Elice M; Chen, Zhuan et al. (2002) Dietary modulation of mitochondrial DNA deletions and copy number after chemotherapy in rats. Mutat Res 501:29-36
Branda, Richard F; Brooks, Elice M; Chen, Zhuan et al. (2002) Nucleic acid deletions and copy number in rats. Comp Med 52:359-62
Brooks, E M; Branda, R F; Nicklas, J A et al. (2001) Molecular description of three macro-deletions and an Alu-Alu recombination-mediated duplication in the HPRT gene in four patients with Lesch-Nyhan disease. Mutat Res 476:43-54
Branda, R F; O'Neill, J P; Brooks, E M et al. (2001) The effect of folate deficiency on the cytotoxic and mutagenic responses to ethyl methanesulfonate in human lymphoblastoid cell lines that differ in p53 status. Mutat Res 473:51-71
Branda, R F; Lafayette, A R; O'Neill, J P et al. (1999) The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents. Mutat Res 427:79-87
Branda, R F; Nigels, E; Lafayette, A R et al. (1998) Nutritional folate status influences the efficacy and toxicity of chemotherapy in rats. Blood 92:2471-6
Branda, R F; Hacker, M; Lafayette, A et al. (1998) Nutritional folate deficiency augments the in vivo mutagenic and lymphocytotoxic activities of alkylating agents. Environ Mol Mutagen 32:33-8
Branda, R F; Lafayette, A R; O'Neill, J P et al. (1997) Effect of folate deficiency on mutations at the hprt locus in Chinese hamster ovary cells exposed to monofunctional alkylating agents. Cancer Res 57:2586-8
Branda, R F; Moore, A L; Hong, R et al. (1996) B-cell proliferation and differentiation in common variable immunodeficiency patients produced by an antisense oligomer to the rev gene of HIV-1. Clin Immunol Immunopathol 79:115-21

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