Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA042385-11S1
Application #
2090710
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1986-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Yin, Xianglei; Zafrullah, Mohammad; Lee, Hyunmi et al. (2009) A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem 24:219-30
Zafrullah, Mohammad; Yin, Xianglei; Haimovitz-Friedman, Adriana et al. (2009) Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun 390:434-40
Zhang, Jianjun; Zafrullah, Mohammad; Yang, Xia et al. (2008) Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther 7:1490-5
Kolesnick, Richard (2002) The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 110:3-8
Liu, J; Mathias, S; Yang, Z et al. (1994) Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase. J Biol Chem 269:3047-52
Haimovitz-Friedman, A; Kan, C C; Ehleiter, D et al. (1994) Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 180:525-35
Kolesnick, R (1994) Signal transduction through the sphingomyelin pathway. Mol Chem Neuropathol 21:287-97
Mathias, S; Kolesnick, R (1993) Ceramide: a novel second messenger. Adv Lipid Res 25:65-90
Joseph, C K; Byun, H S; Bittman, R et al. (1993) Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed. J Biol Chem 268:20002-6
Mathias, S; Younes, A; Kan, C C et al. (1993) Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. Science 259:519-22

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