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Sarafraz-Yazdi, Ehsan; Bowne, Wilbur B; Adler, Victor et al. (2010) Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. Proc Natl Acad Sci U S A 107:1918-23
|
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Deng, Lili; Boujdir, Mohamed; Tremontano, Anthony et al. (2009) A peptide from a ras effector-domain blocks ras-dependent cardiac hypertrophy in myocytes. Ann Clin Lab Sci 39:351-60
|
|
Bowne, Wilbur B; Sookraj, Kelley A; Vishnevetsky, Michael et al. (2008) The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells. Ann Surg Oncol 15:3588-600
|
|
Bowne, Wilbur B; Michl, Josef; Bluth, Martin H et al. (2007) Novel peptides from the RAS-p21 and p53 proteins for the treatment of cancer. Cancer Ther 5B:331-344
|
|
Qu, Yongxia; Adler, Victor; Chu, Tearina et al. (2006) Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes. Front Biosci 11:2420-7
|
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Michl, Josef; Scharf, Bruce; Schmidt, Anna et al. (2006) PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo. Int J Cancer 119:1577-85
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Chie, Lyndon; Chung, Denise; Pincus, Matthew R (2005) Specificity of inhibition of ras-p21 signal transduction by peptides from GTPase activating protein (GAP) and the son-of sevenless (SOS) ras-specific guanine nucleotide exchange protein. Protein J 24:253-8
|
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Smith, Steven; Hyde, Mark; Pincus, Matthew R (2005) Comparison of the predicted structures of loops in the ras-SOS protein bound to a single ras-p21 protein with the crystallographically determined structures in SOS bound to two ras-p21 proteins. Protein J 24:391-8
|
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Adler, Victor; Qu, Yongxia; Smith, Steven J et al. (2005) Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway. Biochemistry 44:10784-95
|
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Rosal, Ramon; Brandt-Rauf, Paul; Pincus, Matthew R et al. (2005) The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosis. Adv Drug Deliv Rev 57:653-60
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