Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA042919-09
Application #
2091007
Study Section
Pathology B Study Section (PTHB)
Project Start
1987-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
094878337
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Blavier, Laurence; Lazaryev, Alisa; Shi, Xiang-He et al. (2010) Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther 10:198-208
Wall, Steven J; Zhong, Zhi-Duan; DeClerck, Yves A (2007) The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrest. J Biol Chem 282:24471-6
Jodele, Sonata; Blavier, Laurence; Yoon, Janet M et al. (2006) Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression. Cancer Metastasis Rev 25:35-43
Wall, Steven J; Werner, Erica; Werb, Zena et al. (2005) Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. J Biol Chem 280:40187-94
Wall, Steven J; Jiang, Yong; Muschel, Ruth J et al. (2003) Meeting report: Proteases, extracellular matrix, and cancer: an AACR Special Conference in Cancer Research. Cancer Res 63:4750-5
Blavier, L; Lazaryev, A; Groffen, J et al. (2001) TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell 12:1457-66
Zhong, Z D; Hammani, K; Bae, W S et al. (2000) NF-Y and Sp1 cooperate for the transcriptional activation and cAMP response of human tissue inhibitor of metalloproteinases-2. J Biol Chem 275:18602-10
DeClerck, Y A (2000) Interactions between tumour cells and stromal cells and proteolytic modification of the extracellular matrix by metalloproteinases in cancer. Eur J Cancer 36:1258-68
Henriet, P; Zhong, Z D; Brooks, P C et al. (2000) Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1. Proc Natl Acad Sci U S A 97:10026-31
Blavier, L; Henriet, P; Imren, S et al. (1999) Tissue inhibitors of matrix metalloproteinases in cancer. Ann N Y Acad Sci 878:108-19

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