Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA043058-03S1
Application #
3184928
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1986-01-01
Project End
1988-11-30
Budget Start
1988-09-01
Budget End
1988-11-30
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Berger, C L; Longley, B J; Imaeda, S et al. (1998) Tumor-specific peptides in cutaneous T-cell lymphoma: association with class I major histocompatibility complex and possible derivation from the clonotypic T-cell receptor. Int J Cancer 76:304-11
Edelson, R L (1998) Cutaneous T-cell lymphoma: a model for selective immunotherapy. Cancer J Sci Am 4:62-71
Hanlon, D J; Berger, C L; Edelson, R L (1998) Photoactivated 8-methoxypsoralen treatment causes a peptide-dependent increase in antigen display by transformed lymphocytes. Int J Cancer 78:70-5
Fargnoli, M C; Edelson, R L; Berger, C L et al. (1997) Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk. Leukemia 11:1338-46
Berger, C L; Wang, N; Christensen, I et al. (1996) The immune response to class I-associated tumor-specific cutaneous T-cell lymphoma antigens. J Invest Dermatol 107:392-7
Imaeda, S; Felli, A; Schmitt, I et al. (1996) Induction of functional empty class I major histocompatibility complex glycoproteins by photoactivated 8-methoxypsoralen. J Invest Dermatol 107:887-90
Longley, J; Tyrrell, L; Lu, S Z et al. (1995) Malignant and normal T cells show random use of T-cell receptor alpha chain variable regions in patients with cutaneous T-cell lymphoma. J Invest Dermatol 105:62-4
Heald, P; Yan, S L; Edelson, R (1994) Profound deficiency in normal circulating T cells in erythrodermic cutaneous T-cell lymphoma. Arch Dermatol 130:198-203
Schmitt, I M; Maxwell, V M; Olack, G A et al. (1994) The specific effects of 8-methoxypsoralen photoadducts on cell growth: HPLC analysis of monoadduct and crosslink formation in cells exposed to split-dose treatment. J Photochem Photobiol B 22:17-21
Tokura, Y; Yagi, J; O'Malley, M et al. (1994) Superantigenic staphylococcal exotoxins induce T-cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinocytes to produce T-cell-activating cytokines. J Invest Dermatol 102:31-8

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