Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043159-10
Application #
2091103
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1986-08-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Fu, Ying; Silverstein, Shana; McCutcheon, Justine N et al. (2018) An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice. Hepatology 67:159-170
Pan, Jishen; Sinclair, Elizabeth; Xuan, Zhuoli et al. (2016) Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein. Mutat Res 789:33-8
Choudhury, Sujata; Dyba, Marcin; Pan, Jishen et al. (2013) Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts. Mutat Res 751-752:15-23
Chung, Fung-Lung; Wu, Mona Y; Basudan, Ahmed et al. (2012) Regioselective formation of acrolein-derived cyclic 1,N(2)-propanodeoxyguanosine adducts mediated by amino acids, proteins, and cell lysates. Chem Res Toxicol 25:1921-8
Pan, Jishen; Awoyemi, Bisola; Xuan, Zhuoli et al. (2012) Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies. Chem Res Toxicol 25:2788-95
Nath, Raghu G; Wu, Mona Y; Emami, Armaghan et al. (2010) Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation. Nutr Cancer 62:622-9
Pan, Jishen; Keffer, Jessica; Emami, Armaghan et al. (2009) Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid. Chem Res Toxicol 22:798-806
Emami, Armaghan; Dyba, Marcin; Cheema, Amrita K et al. (2008) Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: blocking its artifact formation with glutathione. Anal Biochem 374:163-72
Pan, Jishen; Davis, Warren; Trushin, Neil et al. (2006) A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals. Anal Biochem 348:15-23
Chung, Fung-Lung; Komninou, Despina; Zhang, Lei et al. (2005) Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver. Chem Res Toxicol 18:24-7

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