The long term objective of this research is to determine the sequential changes in mammary tissue following irradiation that lead to tumor formation. Specifically this research will quantify and characterize the early alterations in growth potential of mammary cells after radiation exposure and characterize the cell populations that emerge with time during progression to the neoplastic state. Further, these studies will compare and contrast the sequential changes in mammary tissue following the chemical carcinogen 7,12-dimethylbenz[a]anthracene with those changes which occur following irradiation. These studies will also determine whether and how radiation exposure affects the dynamics of the carcinogenic process initiated by a chemical carcinogen. These studies will use the cell dissociation technique and the epithelial focus (EF) assay to examine the induction and dynamics of altered mammary cell populations. This approach allows the examination of the cellular changes which occur with time after in vivo exposure by means of relatively new ex vivo/in vivo and in vivo/in vitro techniques. These studies should help illuminate some of the differences between radiation and chemical carcinogens, if any, as well as provide information on the mechanisms of action and radiation in the carcinogenic process. Further, these studies should provide information on the processes involved in mammary carcinogenesis which may be applicable to understanding the development of mammary cancer in humans.
| Fabre, Kristin M; Ramaiah, Lila; Dregalla, Ryan C et al. (2011) Murine Prkdc polymorphisms impact DNA-PKcs function. Radiat Res 175:493-500 |
| Williams, Eli S; Klingler, Rebekah; Ponnaiya, Brian et al. (2009) Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res 69:2100-7 |
| Carsten, Ronald E; Bachand, Annette M; Bailey, Susan M et al. (2008) Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells. Radiat Res 169:633-8 |
| Hagelstrom, R T; Askin, K F; Williams, A J et al. (2008) DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals. Oncogene 27:6761-9 |
| Williams, Eli S; Stap, Jan; Essers, Jeroen et al. (2007) DNA double-strand breaks are not sufficient to initiate recruitment of TRF2. Nat Genet 39:696-8;author reply 698-9 |
| Bailey, Susan M; Murnane, John P (2006) Telomeres, chromosome instability and cancer. Nucleic Acids Res 34:2408-17 |
| Bailey, S M; Goodwin, E H; Cornforth, M N (2004) Strand-specific fluorescence in situ hybridization: the CO-FISH family. Cytogenet Genome Res 107:14-7 |
| Bailey, Susan M; Brenneman, Mark A; Halbrook, James et al. (2004) The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair (Amst) 3:225-33 |
| Bailey, Susan M; Brenneman, Mark A; Goodwin, Edwin H (2004) Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res 32:3743-51 |
| Bailey, Susan M; Cornforth, Michael N; Ullrich, Robert L et al. (2004) Dysfunctional mammalian telomeres join with DNA double-strand breaks. DNA Repair (Amst) 3:349-57 |
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