The applicants proposed to develop adaptive imaging algorithms and instrumentation to compensate for tissue-induced ultrasonic image degradation. Theoretical and simulation studies are proposed to optimize the accuracy, stability, and speed of adaptive algorithms and to explore the impact of transducer design on adaptive imaging. In addition, the applicants proposed to collect high-quality tissue echo data and through-transmission data to investigate the nature of tissue- induced image degradation. The adaptive imaging techniques would be implemented in real-time on an advanced engineering prototype scanner. Synthetic receive aperture (SRA) techniques, combined with adaptive imaging, would be used to address 1000 and 2000 element two dimensional (2-D) arrays and to form very high resolution images. Specialized analog multiplexers and other hardware would be constructed for this system. Clinical trials would evaluate the performance of the adaptive/SRA system in imaging breast lesions and breast microcalcifications, and in renal and adrenal gland imaging studies. The applicants hypothesized that the proposed techniques and system would markedly improve ultrasonic image quality in a wide variety of clinical applications.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043334-11
Application #
2007600
Study Section
Special Emphasis Panel (ZRG7-SSS-X (33))
Project Start
1986-08-01
Project End
1999-11-30
Budget Start
1996-12-01
Budget End
1997-11-30
Support Year
11
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Dahl, Jeremy J; McAleavey, Stephen A; Pinton, Gianmarco F et al. (2006) Adaptive imaging on a diagnostic ultrasound scanner at quasi real-time rates. IEEE Trans Ultrason Ferroelectr Freq Control 53:1832-43
Dahl, Jeremy J; Soo, Mary S; Trahey, Gregg E (2005) Spatial and temporal aberrator stability for real-time adaptive imaging. IEEE Trans Ultrason Ferroelectr Freq Control 52:1504-17
Dahl, Jeremy J; Guenther, Drake A; Trahey, Gregg E (2005) Adaptive imaging and spatial compounding in the presence of aberration. IEEE Trans Ultrason Ferroelectr Freq Control 52:1131-44
Dahl, Jeremy J; Soo, Mary S; Trahey, Gregg E (2004) Clinical evaluation of combined spatial compounding and adaptive imaging in breast tissue. Ultrason Imaging 26:203-16
Fernandez, Anna T; Gammelmark, Kim L; Dahl, Jeremy J et al. (2003) Synthetic elevation beamforming and image acquisition capabilities using an 8 x 128 1.75D array. IEEE Trans Ultrason Ferroelectr Freq Control 50:40-57
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Anderson, M E; McKeag, M S; Trahey, G E (2000) The impact of sound speed errors on medical ultrasound imaging. J Acoust Soc Am 107:3540-8
Anderson, M E; Trahey, G E (1998) The direct estimation of sound speed using pulse-echo ultrasound. J Acoust Soc Am 104:3099-106
Anderson, M E; Soo, M S; Bentley, R C et al. (1997) The detection of breast microcalcifications with medical ultrasound. J Acoust Soc Am 101:29-39
Bohs, L N; Friemel, B H; Trahey, G E (1995) Experimental velocity profiles and volumetric flow via two-dimensional speckle tracking. Ultrasound Med Biol 21:885-98

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