Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA043540-09
Application #
2091197
Study Section
Pathology B Study Section (PTHB)
Project Start
1987-04-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Walter and Eliza Hall Institute Medical Research
Department
Type
DUNS #
City
Victoria
State
Country
Australia
Zip Code
VIC, -3052
Campbell, Kirsteen J; Vandenberg, Cassandra J; Anstee, Natasha S et al. (2017) Mnt modulates Myc-driven lymphomagenesis. Cell Death Differ 24:2117-2126
Anstee, Natasha S; Vandenberg, Cassandra J; Campbell, Kirsteen J et al. (2017) Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice. Cell Death Differ 24:397-408
Vandenberg, C J; Motoyama, N; Cory, S (2016) FoxO3 suppresses Myc-driven lymphomagenesis. Cell Death Dis 6:e2046
Vandenberg, Cassandra J; Waring, Paul; Strasser, Andreas et al. (2014) Plasmacytomagenesis in E?-v-abl transgenic mice is accelerated when apoptosis is restrained. Blood 124:1099-109
Vandenberg, C J; Josefsson, E C; Campbell, K J et al. (2014) Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice. Cell Death Differ 21:676-84
Vandenberg, Cassandra J; Cory, Suzanne (2013) ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia. Blood 121:2285-8
Mason, Kylie D; Lin, Ann; Robb, Lorraine et al. (2013) Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proc Natl Acad Sci U S A 110:2599-604
Slape, Christopher I; Saw, Jesslyn; Jowett, Jeremy B M et al. (2012) Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome. Blood 120:2475-83
Happo, L; Phipson, B; Smyth, G K et al. (2012) Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs. Cell Death Dis 3:e306
Grabow, S; Waring, P; Happo, L et al. (2012) Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice. Cell Death Differ 19:623-32

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