Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA043618-04
Application #
3185866
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1989-12-11
Project End
1993-06-30
Budget Start
1993-02-01
Budget End
1993-06-30
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Liebermann, Dan A; Hoffman, Barbara (2002) Myeloid differentiation (MyD) primary response genes in hematopoiesis. Oncogene 21:3391-402
Vairapandi, Mariappan; Balliet, Arthur G; Hoffman, Barbara et al. (2002) GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol 192:327-38
Zhang, W; Hoffman, B; Liebermann, D A (2001) Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis. Int J Oncol 18:749-57
Balliet, A G; Hatton, K S; Hoffman, B et al. (2001) Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (Gadd45beta) gene. DNA Cell Biol 20:239-47
Azam, N; Vairapandi, M; Zhang, W et al. (2001) Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. J Biol Chem 276:2766-74
Vairapandi, M; Azam, N; Balliet, A G et al. (2000) Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control. J Biol Chem 275:16810-9
Amanullah, A; Hoffman, B; Liebermann, D A (2000) Deregulated E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15(INK4B) and p16(INK4A). Blood 96:475-82
Zhang, W; Bae, I; Krishnaraju, K et al. (1999) CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 18:4899-907
Liebermann, D A; Gregory, B; Hoffman, B (1998) AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol 12:685-700
Guillouf, C; Rosselli, F; Sjin, R T et al. (1998) Role of a mutant p53 protein in apoptosis: characterization of a function independent of transcriptional trans-activation. Int J Oncol 13:107-14

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