Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA044247-11
Application #
2091406
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1987-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Meira, Lisiane B; Cheo, David L; Reis, Antonio M et al. (2002) Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer. DNA Repair (Amst) 1:929-34
Fischhaber, Paula L; Gerlach, Valerie L; Feaver, William J et al. (2002) Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides. J Biol Chem 277:37604-11
van der Horst, Gijsbertus T J; Meira, Lisiane; Gorgels, Theo G M F et al. (2002) UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. DNA Repair (Amst) 1:143-57
Meira, L B; Devaraj, S; Kisby, G E et al. (2001) Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress. Cancer Res 61:5552-7
Mullenders, L H; Berneburg, M (2001) Photoimmunology and nucleotide excision repair: impact of transcription coupled and global genome excision repair. J Photochem Photobiol B 65:97-100
Queimado, L; Rao, M; Schultz, R A et al. (2001) Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. Nucleic Acids Res 29:1884-91
Meira, L B; Reis, A M; Cheo, D L et al. (2001) Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions. Mutat Res 477:51-8
Friedberg, E C; Bond, J P; Burns, D K et al. (2000) Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition. Mutat Res 459:99-108
Cheo, D L; Meira, L B; Burns, D K et al. (2000) Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors. Cancer Res 60:1580-4
van Oosten, M; Rebel, H; Friedberg, E C et al. (2000) Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. Proc Natl Acad Sci U S A 97:11268-73

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