Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA044735-07A1
Application #
2091590
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1988-07-01
Project End
1999-12-31
Budget Start
1996-02-01
Budget End
1996-12-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
City of Hope/Beckman Research Institute
Department
Type
DUNS #
City
Duarte
State
CA
Country
United States
Zip Code
91010
Wang, Yuanzhong; Zhou, Dujin; Phung, Sheryl et al. (2017) SGK3 sustains ER? signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A 114:E1500-E1508
Kanaya, Noriko; Somlo, George; Wu, Jun et al. (2017) Characterization of patient-derived tumor xenografts (PDXs) as models for estrogen receptor positive (ER+HER2- and ER+HER2+) breast cancers. J Steroid Biochem Mol Biol 170:65-74
Chan, Hei Jason; Petrossian, Karineh; Chen, Shiuan (2016) Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells. J Steroid Biochem Mol Biol 161:73-83
Chan, Hei Jason; Li, Haiqing; Liu, Zheng et al. (2015) SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients. Oncotarget 6:25815-27
Wang, Yuanzhong; Xu, Wanping; Zhou, Dujin et al. (2014) Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. J Biol Chem 289:4815-26
Wang, Yuanzhong; Zhou, Dujin; Chen, Shiuan (2014) SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol 28:935-48
Wong, Cynthie; Wang, Xin; Smith, David et al. (2012) AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies. Breast Cancer Res Treat 134:671-81
Wong, Cynthie; Chen, Shiuan (2012) The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance. J Steroid Biochem Mol Biol 131:83-92
Wang, Yuanzhong; Zhou, Dujin; Phung, Sheryl et al. (2011) SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol 25:72-82
Su, Bin; Wong, Cynthie; Hong, Yanyan et al. (2011) Growth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms. J Steroid Biochem Mol Biol 123:101-8

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