Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA045158-08
Application #
3188192
Study Section
Experimental Virology Study Section (EVR)
Project Start
1986-09-01
Project End
1994-06-30
Budget Start
1994-02-05
Budget End
1994-06-30
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20817
Xu, Liang; Huang, Cheng-Cheng; Huang, Weiqun et al. (2002) Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes. Mol Cancer Ther 1:337-46
Sherif, Z A; Nakai, S; Pirollo, K F et al. (2001) Downmodulation of bFGF-binding protein expression following restoration of p53 function. Cancer Gene Ther 8:771-82
Xu, L; Pirollo, K F; Chang, E H (2001) Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapy. J Control Release 74:115-28
Xu, L; Tang, W H; Huang, C C et al. (2001) Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv. Mol Med 7:723-34
Pirollo, K F; Bouker, K B; Chang, E H (2000) Does p53 status influence tumor response to anticancer therapies? Anticancer Drugs 11:419-32
Xu, L; Pirollo, K F; Tang, W H et al. (1999) Transferrin-liposome-mediated systemic p53 gene therapy in combination with radiation results in regression of human head and neck cancer xenografts. Hum Gene Ther 10:2941-52
Pirollo, K F; Hao, Z; Rait, A et al. (1997) Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells. Biochem Biophys Res Commun 230:196-201
Xu, L; Pirollo, K F; Chang, E H (1997) Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro. Hum Gene Ther 8:467-75
Pirollo, K F; Hao, Z; Rait, A et al. (1997) p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy. Oncogene 14:1735-46
Srivastava, S; Wang, S; Tong, Y A et al. (1993) Several mutant p53 proteins detected in cancer-prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53. Oncogene 8:2449-56

Showing the most recent 10 out of 16 publications