Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA047572-09
Application #
2092647
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1988-04-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ariad Pharmaceuticals, Inc.
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Clark, E A; King, W G; Brugge, J S et al. (1998) Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol 142:573-86
King, W G; Mattaliano, M D; Chan, T O et al. (1997) Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol 17:4406-18
Gao, J; Zoller, K E; Ginsberg, M H et al. (1997) Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J 16:6414-25
Rusanescu, G; Qi, H; Thomas, S M et al. (1995) Calcium influx induces neurite growth through a Src-Ras signaling cassette. Neuron 15:1415-25
Clark, E A; Shattil, S J; Ginsberg, M H et al. (1994) Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem 269:28859-64
Clark, E A; Shattil, S J; Brugge, J S (1994) Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci 19:464-9
Clark, E A; Brugge, J S (1993) Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol 13:1863-71
Fox, J E; Lipfert, L; Clark, E A et al. (1993) On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. J Biol Chem 268:25973-84
Haimovich, B; Lipfert, L; Brugge, J S et al. (1993) Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem 268:15868-77
Schmidt, J W; Brugge, J S; Nelson, W J (1992) pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation. J Cell Biol 116:1019-33

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