Abstract

The role of immunity in altering the growth of papillomavirus lesions is largely unexplored territory. Ethical considerations preclude interventional studies on patients. We propose a comprehensive evaluation in rabbits of immunity to Shope papilloma. The role of infiltrating T cells, B cells, macrophages/monocytes, and Langerhans cells will be assessed. We will conduct functional studies of T cells in several independent measures of anti-papilloma activity. The contribution of serum antibody will also be evaluated. We will examine the potential for immunoprophylaxis and immunotherapy of several Shope papillomavirus-associated antigens.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA047622-03
Application #
3191365
Study Section
Special Emphasis Panel (SRC (48))
Project Start
1988-05-01
Project End
1993-04-30
Budget Start
1990-05-01
Budget End
1991-04-30
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Esteves, Pedro J; Abrantes, Joana; Baldauf, Hanna-Mari et al. (2018) The wide utility of rabbits as models of human diseases. Exp Mol Med 50:66
Cooper, T K; Griffith, J W; Chroneos, Z C et al. (2017) Spontaneous Lung Lesions in Aging Laboratory Rabbits ( Oryctolagus cuniculus). Vet Pathol 54:178-187
Christensen, Neil D; Budgeon, Lynn R; Cladel, Nancy M et al. (2017) Recent advances in preclinical model systems for papillomaviruses. Virus Res 231:108-118
Christensen, Neil D (2016) HPV disease transmission protection and control. Microb Cell 3:476-490
Cladel, Nancy M; Budgeon, Lynn R; Balogh, Karla K et al. (2016) Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue. Virology 488:73-80
Hu, Jiafen; Budgeon, Lynn R; Cladel, Nancy M et al. (2015) Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model. J Gen Virol 96:3554-65
Peng, Xuwen; Roshwalb, Sara; Cooper, Timothy K et al. (2015) High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain. Vet Ophthalmol 18:186-90
Hu, Jiafen; Budgeon, Lynn R; Balogh, Karla K et al. (2014) Long-peptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1 transgenic rabbits. Trials Vaccinol 3:134-142
Hu, Jiafen; Brendle, Sarah; Balogh, Karla et al. (2014) Antibody detection in tear samples as a surrogate to monitor host immunity against papillomavirus infections in vaccinated and naturally infected hosts. J Gen Virol 95:2030-7
Cladel, Nancy M; Budgeon, Lynn R; Hu, Jiafen et al. (2013) Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus. Virology 438:70-83

Showing the most recent 10 out of 79 publications