This is a competing proposal for research in statistical issues related to environmental risk for carcinogenicity and teratology. The proposed problems are motivated both by toxicological studies in rodents and epidemiological studies in humans.
Specific aims i nclude: Application of local likelihood methods to three-state models for rodent carcinogenicity experiments; Developing improved approaches to quantitative risk assessment based on epidemiological data; and Developing new methods for the analysis of correlated date. Empirical data analysis will play a central role in achieving these specific aims. In addition to addressing important real world questions motivated by environmental risk assessment, the proposed research offers useful contributions to general statistical methodology in survival analysis, meta-analysis, clustered data methods, hierarchical modeling and analysis of multiple outcomes.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA048061-12
Application #
6042555
Study Section
Special Emphasis Panel (ZRG1-SNEM-5 (01))
Program Officer
Erickson, Burdette (BUD) W
Project Start
1988-08-01
Project End
2003-02-28
Budget Start
2000-03-15
Budget End
2001-02-28
Support Year
12
Fiscal Year
2000
Total Cost
$163,277
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Cai, Tianxi; Parast, Layla; Ryan, Louise (2010) Meta-analysis for rare events. Stat Med 29:2078-89
Horton, Nicholas J; Roberts, Kevin; Ryan, Louise et al. (2008) A maximum likelihood latent variable regression model for multiple informants. Stat Med 27:4992-5004