Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048075-09
Application #
2092894
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1988-08-15
Project End
1998-05-31
Budget Start
1996-09-01
Budget End
1998-05-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Miller, Catriona H T; Graham, Laura; Bear, Harry D (2010) Phenotype, functions and fate of adoptively transferred tumor draining lymphocytes activated ex vivo in mice with an aggressive weakly immunogenic mammary carcinoma. BMC Immunol 11:54
Chin, Cynthia S; Miller, Catriona H T; Graham, Laura et al. (2004) Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes. Int Immunol 16:1283-94
Parviz, Maryam; Chin, Cynthia S; Graham, Laura J et al. (2003) Successful adoptive immunotherapy with vaccine-sensitized T cells, despite no effect with vaccination alone in a weakly immunogenic tumor model. Cancer Immunol Immunother 52:739-50
Chin, Cynthia S; Bear, Harry D (2002) Sentinel node mapping identifies vaccine-draining lymph nodes with tumor-specific immunological activity. Ann Surg Oncol 9:94-103
Chin, C S; Graham, L J; Hamad, G G et al. (2001) Bryostatin/ionomycin-activated T cells mediate regression of established tumors. J Surg Res 98:108-15
Kos, F J; Cornell, D L; Lipke, A B et al. (2000) Protective role of IL-2 during activation of T cells with bryostatin 1. Int J Immunopharmacol 22:645-52
Kos, F J; Bear, H D (1998) Involvement of protein kinase C-delta in CD28-triggered cytotoxicity mediated by a human leukaemic cell line YT. Immunology 94:575-9
Baldwin, N G; Rice, C D; Tuttle, T M et al. (1997) Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. I. Characterization and in vivo anti-tumor activity of glioma-sensitized lymphocytes. J Neurooncol 32:19-28
Rice, C D; Baldwin, N G; Biron, R T et al. (1997) Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. II. Cytokine production and in vivo efficacy of glioma-sensitized lymphocytes. J Neurooncol 32:29-38
Merchant, R E; Baldwin, N G; Rice, C D et al. (1997) Adoptive immunotherapy of malignant glioma using tumor-sensitized T lymphocytes. Neurol Res 19:145-52

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