Abstract

The overall goal of this project is the development of proton magnetic resonance spectroscopic imaging (MRSI) techniques and their subsequent application for aiding in the diagnosis and treatment monitoring of patients with tumors. As a noninvasive tool providing unique biochemical information supplemental to conventional imaging, in vivo MRSI has been shown to have a valuable role in the study of cancer. However, significant technical improvements, particularly for the reliable acquisition of volumetric MRSI data from tumors throughout the body, are needed to fully realize the clinical potential of this powerful imaging modality. This proposal is focused on the continued technical development of innovative spectroscopic techniques for the robust and efficient collection, quantification, and display of this information. The techniques will be tested on phantoms, normal volunteers, as well as patients with brain tumors, metastatic neck nodes of squamous cell carcinomas, and breast cancer. In parallel with the continued technical development, we will conduct a focused, well-controlled clinical study comparing the abilities of proton MRSI and FDG PET for differentiating radiation necrosis from recurrent glial tumors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA048269-11
Application #
6533126
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Menkens, Anne E
Project Start
1990-07-23
Project End
2004-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
11
Fiscal Year
2002
Total Cost
$244,120
Indirect Cost

  Institution

Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Gu, Meng; Liu, Chunlei; Spielman, Daniel M (2009) Parallel spectroscopic imaging reconstruction with arbitrary trajectories using k-space sparse matrices. Magn Reson Med 61:267-72
Geraghty, Patricia R; van den Bosch, Maurice A A J; Spielman, Daniel M et al. (2008) MRI and (1)H MRS of the breast: presence of a choline peak as malignancy marker is related to K21 value of the tumor in patients with invasive ductal carcinoma. Breast J 14:574-80
Kim, Dong-Hyun; Henry, Roland; Spielman, Daniel M (2007) Fast multivoxel two-dimensional spectroscopic imaging at 3 T. Magn Reson Imaging 25:1155-61
Mayer, Dirk; Levin, Yakir S; Hurd, Ralph E et al. (2006) Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imaging. Magn Reson Med 56:932-7
Kim, Dong-Hyun; Spielman, Daniel M (2006) Reducing gradient imperfections for spiral magnetic resonance spectroscopic imaging. Magn Reson Med 56:198-203
Mayer, Dirk; Kim, Dong-Hyun; Adalsteinsson, Elfar et al. (2006) Fast CT-PRESS-based spiral chemical shift imaging at 3 Tesla. Magn Reson Med 55:974-8
Spencer, D C; Szumowski, J; Kraemer, D F et al. (2005) Temporal lobe magnetic resonance spectroscopic imaging following selective amygdalohippocampectomy for treatment-resistant epilepsy. Acta Neurol Scand 112:6-12
Kim, Dong-hyun; Margolis, Daniel; Xing, Lei et al. (2005) In vivo prostate magnetic resonance spectroscopic imaging using two-dimensional J-resolved PRESS at 3 T. Magn Reson Med 53:1177-82
Kim, Dong-Hyun; Adalsteinsson, Elfar; Spielman, Daniel M (2004) Spiral readout gradients for the reduction of motion artifacts in chemical shift imaging. Magn Reson Med 51:458-63
Kim, Dong-Hyun; Adalsteinsson, Elfar; Glover, Gary H et al. (2002) Regularized higher-order in vivo shimming. Magn Reson Med 48:715-22

Showing the most recent 10 out of 31 publications