Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA049515-05
Application #
3193662
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1989-04-01
Project End
1994-03-31
Budget Start
1993-04-01
Budget End
1994-03-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Coustry, F; Hu, Q; de Crombrugghe, B et al. (2001) CBF/NF-Y functions both in nucleosomal disruption and transcription activation of the chromatin-assembled topoisomerase IIalpha promoter. Transcription activation by CBF/NF-Y in chromatin is dependent on the promoter structure. J Biol Chem 276:40621-30
Coustry, F; Sinha, S; Maity, S N et al. (1998) The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex. Biochem J 331 ( Pt 1):291-7
Bi, W; Wu, L; Coustry, F et al. (1997) DNA binding specificity of the CCAAT-binding factor CBF/NF-Y. J Biol Chem 272:26562-72
Kim, I S; Sinha, S; de Crombrugghe, B et al. (1996) Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule. Mol Cell Biol 16:4003-13
Coustry, F; Maity, S N; Sinha, S et al. (1996) The transcriptional activity of the CCAAT-binding factor CBF is mediated by two distinct activation domains, one in the CBF-B subunit and the other in the CBF-C subunit. J Biol Chem 271:14485-91
Sinha, S; Kim, I S; Sohn, K Y et al. (1996) Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex. Mol Cell Biol 16:328-37
Sinha, S; Maity, S N; Seldin, M F et al. (1996) Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. Genomics 37:260-3
Sinha, S; Maity, S N; Lu, J et al. (1995) Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci U S A 92:1624-8
Coustry, F; Maity, S N; de Crombrugghe, B (1995) Studies on transcription activation by the multimeric CCAAT-binding factor CBF. J Biol Chem 270:468-75
Sohn, K Y; Maity, S N; de Crombrugghe, B (1994) Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA. Gene 139:147-53

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