Abstract

The objectives of this research proposal are to examine in a non-convergent manner the synthesis and attendant chemistry of the potent antitumor antibiotics esperamicin A2, calicheamicin, and neocarzinostatin chromophore A, (1, 2 and 3 respectively). The structural factors that influence their proposed biological mode of action will be examined. This involves examining the effect of substituent/structural effects upon the relative rate of 1,4-diyl formation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050512-05
Application #
2093821
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Magnus, Philip; Turnbull, Rachel (2006) Thermal and acid-catalyzed Hofmann-Martius rearrangement of 3-N-aryl-2-oxindoles into 3-(arylamino)-2-oxindoles. Org Lett 8:3497-9
Goldberg, Frederick W; Magnus, Philip; Turnbull, Rachel (2005) A mild thermal and acid-catalyzed rearrangement of O-aryl ethers into ortho-hydroxy arenes. Org Lett 7:4531-4