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Ross, David; Siegel, David (2017) Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch. Front Physiol 8:595
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Xiong, Rui; Zhou, Wenbo; Siegel, David et al. (2015) A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T ?-Synuclein Toxicity. Mol Pharmacol 88:1045-54
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Chang, Chuan-Hsin; Drechsel, Derek A; Kitson, Russell R A et al. (2014) 19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity. Mol Pharmacol 85:849-57
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Siegel, David; Yan, Chao; Ross, David (2012) NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol 83:1033-40
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Reigan, Philip; Siegel, David; Guo, Wenchang et al. (2011) A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins. Mol Pharmacol 79:823-32
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Siegel, David; Shieh, Biehuoy; Yan, Chao et al. (2011) Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells. J Pharmacol Exp Ther 336:874-80
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Guo, Wenchang; Siegel, David; Ross, David (2008) Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation. J Pharm Sci 97:5147-57
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Yan, Chao; Kepa, Jadwiga K; Siegel, David et al. (2008) Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Mol Pharmacol 74:1657-65
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Guo, Wenchang; Reigan, Philip; Siegel, David et al. (2008) Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos 36:2050-7
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