Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA051735-09S1
Application #
2712636
Study Section
Chemical Pathology Study Section (CPA)
Program Officer
Cole, John S
Project Start
1990-05-01
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Robinson-Benion, C; Jensen, R A; Holt, J T (2000) Analysis of cancer gene functions through gene inhibition with antisense oligonucleotides. Methods Enzymol 314:499-506
Abbott, D W; Thompson, M E; Robinson-Benion, C et al. (1999) BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J Biol Chem 274:18808-12
Abbott, D W; Holt, J T (1999) Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J Biol Chem 274:2732-42
Abbott, D W; Freeman, M L; Holt, J T (1998) Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst 90:978-85
Abbott, D W; Holt, J T (1997) Finkel-Biskis-Reilly osteosarcoma virus v-Fos inhibits adipogenesis and both the activity and expression of CCAAT/enhancer binding protein alpha, a key regulator of adipocyte differentiation. J Biol Chem 272:32454-62
Abbott, D W; Holt, J T (1997) Finkel-Biskis-Reilly mouse osteosarcoma virus v-fos inhibits the cellular response to ionizing radiation in a myristoylation-dependent manner. J Biol Chem 272:14005-8
Jotte, R M; Holt, J T (1996) Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma. J Cell Biol 135:457-67
Robinson-Benion, C; Holt, J T (1995) Antisense techniques. Methods Enzymol 254:363-75
Robinson-Benion, C; Li, Y X; Holt, J T (1994) Gene transplantation: combined antisense inhibition and gene replacement strategies. Leukemia 8 Suppl 1:S152-5
Jotte, R M; Kamata, N; Holt, J T (1994) Myristylation-dependent transactivation by FBR v-fos is regulated by C/EBP. J Biol Chem 269:16383-96

Showing the most recent 10 out of 15 publications