Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA052461-05
Application #
2094747
Study Section
Radiation Study Section (RAD)
Project Start
1992-03-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Yan, Yiyi; Akhter, Shamima; Zhang, Xiaoshan et al. (2010) The multifunctional SNM1 gene family: not just nucleases. Future Oncol 6:1015-29
Akhter, Shamima; Lam, Yung C; Chang, Sandy et al. (2010) The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Aging Cell 9:1047-56
Liu, Lingling; Akhter, Shamima; Bae, Jae-Bum et al. (2009) SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Cell Cycle 8:628-38
Bae, J-B; Mukhopadhyay, S S; Liu, L et al. (2008) Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene 27:5045-56
Akhter, Shamima; Legerski, Randy J (2008) SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Biochem Biophys Res Commun 377:236-41
Geng, Liyi; Zhang, Xiaoshan; Zheng, Shu et al. (2007) Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol Cell Biol 27:2625-35
Ahkter, Shamima; Richie, Christopher T; Zhang, Nianxiang et al. (2005) Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol 25:10071-8
Zhang, Xiaoshan; Succi, Janice; Feng, Zhaohui et al. (2004) Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol 24:9207-20
Akhter, Shamima; Richie, Christopher T; Deng, Jian Min et al. (2004) Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol 24:10448-55
Leonard, Deana; Ajuh, Paul; Lamond, Angus I et al. (2003) hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. Biochem Biophys Res Commun 308:793-801

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