Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA053106-04A2
Application #
2007877
Study Section
Special Emphasis Panel (ZRG4-ALTX-4)
Project Start
1991-07-05
Project End
1999-06-30
Budget Start
1996-09-17
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Thomson, Margaret M S; Hines, Ronald N; Schuetz, Erin G et al. (2016) Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver. Drug Metab Dispos 44:999-1004
Hines, R N (2013) Developmental expression of drug metabolizing enzymes: impact on disposition in neonates and young children. Int J Pharm 452:3-7
Koukouritaki, Sevasti B; Poch, Mark T; Henderson, Marilyn C et al. (2007) Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther 320:266-73
Krueger, Sharon K; Vandyke, Jonathan E; Williams, David E et al. (2006) The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines. Drug Metab Rev 38:139-47
Vyas, Piyush M; Roychowdhury, Sanjoy; Koukouritaki, Sevasti B et al. (2006) Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases. J Pharmacol Exp Ther 319:497-505
Koukouritaki, Sevasti B; Poch, Mark T; Cabacungan, Erwin T et al. (2005) Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. Mol Pharmacol 68:383-92
Zheng, Yi-Min; Henne, Kirk R; Charmley, Patrick et al. (2003) Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis. Toxicol Appl Pharmacol 186:119-26
Hines, Ronald N; Luo, Zhaohui; Hopp, Kathleen A et al. (2003) Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). J Pharmacol Exp Ther 306:1210-8
Johnsrud, Elizabeth K; Koukouritaki, Sevasti B; Divakaran, Karthika et al. (2003) Human hepatic CYP2E1 expression during development. J Pharmacol Exp Ther 307:402-7
Stevens, Jeffrey C; Hines, Ronald N; Gu, Chungang et al. (2003) Developmental expression of the major human hepatic CYP3A enzymes. J Pharmacol Exp Ther 307:573-82

Showing the most recent 10 out of 21 publications