Abstract

The overall aim of the application is to characterize cellular transcription factors which are involved in basal and tax-mediated transactivation of the HTLV-1 LTR.
Specific aims i nclude (1) characterizing the interaction of SP and ATF/CREB proteins with tax and promoter elements in the LTR and impact on LTR activity. (2) Examine interaction of AP-1 and ATF/CREB proteins with tax and promoter elements in the LTR. (3) Examine the role of the tax response element in basal and tax-mediated LTR activity. (4) Examine properties of HTLV-1 variants containing mutations in specific promoter regions which disrupt interaction with SP:ATF/CREB and AP:ATF/CREB protein complexes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA054559-05
Application #
2608080
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Cole, John S
Project Start
1991-04-01
Project End
2000-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Mulherkar, Ria; Karabudak, Aykan; Ginwala, Rashida et al. (2018) In vivo and in vitro immunogenicity of novel MHC class I presented epitopes to confer protective immunity against chronic HTLV-1 infection. Vaccine 36:5046-5057
Ginwala, Rashida; Caruso, Breanna; Khan, Zafar K et al. (2017) HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-?c-/- (RAG1-Hu) and BLT Mice. J Neuroimmune Pharmacol 12:504-520
Pustylnikov, Sergey; Dave, Rajnish S; Khan, Zafar K et al. (2016) Short Communication: Inhibition of DC-SIGN-Mediated HIV-1 Infection by Complementary Actions of Dendritic Cell Receptor Antagonists and Env-Targeting Virus Inactivators. AIDS Res Hum Retroviruses 32:93-100
Ginwala, Rashida; McTish, Emily; Raman, Chander et al. (2016) Apigenin, a Natural Flavonoid, Attenuates EAE Severity Through the Modulation of Dendritic Cell and Other Immune Cell Functions. J Neuroimmune Pharmacol 11:36-47
Sehgal, Mohit; Zeremski, Marija; Talal, Andrew H et al. (2015) IFN-?-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment. J Interferon Cytokine Res 35:698-709
Jain, Pooja; Lavorgna, Alfonso; Sehgal, Mohit et al. (2015) Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology 12:23
Zhao, Xuesen; Guo, Fang; Comunale, Mary Ann et al. (2015) Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2. Antimicrob Agents Chemother 59:206-16
Sagar, Divya; Masih, Shet; Schell, Todd et al. (2014) In vivo immunogenicity of Tax(11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine. Vaccine 32:3274-84
Jaworski, Elizabeth; Narayanan, Aarthi; Van Duyne, Rachel et al. (2014) Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. J Biol Chem 289:22284-305
Shirazi, Jasmine; Shah, Sonia; Sagar, Divya et al. (2013) Epigenetics, drugs of abuse, and the retroviral promoter. J Neuroimmune Pharmacol 8:1181-96

Showing the most recent 10 out of 46 publications