Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA055578-04A2
Application #
2096707
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1992-03-05
Project End
1999-03-31
Budget Start
1996-04-09
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Pathology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Tang, Chi-Hui; Wei, Wei; Hanes, Martha A et al. (2013) Hepatocarcinogenesis driven by GSNOR deficiency is prevented by iNOS inhibition. Cancer Res 73:2897-904
Tang, Chi-Hui; Seeley, Eric J; Huang, Xiaozhu et al. (2013) Increased susceptibility to Klebsiella pneumonia and mortality in GSNOR-deficient mice. Biochem Biophys Res Commun 442:122-6
Wang, Qian; Na, Bing; Ou, Jing-hsiung James et al. (2012) Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS One 7:e36818
Tang, Chi-Hui; Wei, Wei; Liu, Limin (2012) Regulation of DNA repair by S-nitrosylation. Biochim Biophys Acta 1820:730-5
Ozawa, Kentaro; Tsumoto, Hiroki; Wei, Wei et al. (2012) Proteomic analysis of the role of S-nitrosoglutathione reductase in lipopolysaccharide-challenged mice. Proteomics 12:2024-35
Na, Bing; Huang, Zhiming; Wang, Qian et al. (2011) Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury. PLoS One 6:e26240
Wei, Wei; Yang, Zhiyong; Tang, Chi-Hui et al. (2011) Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 32:973-7
Zhou, Jie; Tan, Thomas; Tian, Yongjun et al. (2011) Kruppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology 54:109-21
Sir, Donna; Tian, Yongjun; Chen, Wen-ling et al. (2010) The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci U S A 107:4383-8
Zheng, Yanyan; Chen, Wen-ling; Louie, Stan G et al. (2007) Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice. Hepatology 45:16-21

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