African Americans share a disproportionate burden of lung cancer incidence and mortality; Mexican Americans exhibit substantially lower rates. These racial differences may represent interactions of environmental and genetic influences. This multidisciplinary study of genetic susceptibility to lung cancer in African Americans and Mexican Americans will incorporate and integrate epidemiologic, cytogenetic, molecular, and socio-psychological data. A case control study of 100 black African American and 100 Mexican American patients with previously untreated lung cancer, ascertained from The University of Texas M.D. Anderson Cancer Center, St. Joseph Hospital, Hermann Hospital and Lyndon Baines Johnson Hospital is planned. Two hundred (200) controls from each ethnic group, selected from local community centers will be age- and sex-frequency matched to the cases. Environmental exposures, family history, dietary intake, and socio-psychological factors will be ascertained by personal interview. Primary chromosome changes and bleomycin-induced chromosome breaks in lymphocyte cultures of cases and controls, and in lung tissue of cases will be assessed and the role of confounding with carcinogenic exposures will be examined. The molecular component will focus on p53 alterations in lung cancer tissue, dysplastic bronchial epithelia and peripheral lymphocytes of cases, and in peripheral lymphocytes of controls identified as current smokers. The sociodemographic component will focus on inter and intra-ethnic differences in perceived risk of disease. Since lung cancer is the leading cause of cancer mortality, the identification of genetic markers of risk has great potential for cancer control. The use of genetic markers of risk enhances the power of this multidisciplinary epidemiologic research project.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055769-04
Application #
2096879
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1994-09-06
Budget End
1995-08-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Feng, Yun; Wang, Yanru; Liu, Hongliang et al. (2018) Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer. Mol Carcinog 57:216-224
Liu, Hongliang; Liu, Zhensheng; Wang, Yanru et al. (2017) Functional variants in DCAF4 associated with lung cancer risk in European populations. Carcinogenesis 38:541-551
Feng, Yun; Wang, Yanru; Liu, Hongliang et al. (2017) Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium. Sci Rep 7:825
Pan, Yongchu; Liu, Hongliang; Wang, Yanru et al. (2017) Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 7:44634
Yin, Jieyun; Liu, Hongliang; Liu, Zhensheng et al. (2017) Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus. Mol Carcinog 56:1663-1672
Zhou, Fei; Wang, Yanru; Liu, Hongliang et al. (2017) Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. Mol Carcinog 56:1227-1238
Patel, Yesha M; Park, Sunghim L; Han, Younghun et al. (2016) Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. Cancer Res 76:5768-5776
Kang, Xiaozheng; Liu, Hongliang; Onaitis, Mark W et al. (2016) Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. Carcinogenesis 37:280-289
Dunkhase, Eva; Ludwig, Kerstin U; Knapp, Michael et al. (2016) Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data. Genom Data 10:22-9
Fehringer, Gordon; Kraft, Peter; Pharoah, Paul D et al. (2016) Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. Cancer Res 76:5103-14

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